EFMC-ISCB 2023

EFMC International Symposium on Chemical Biology

Jointly organised with the Swiss Chemical Society, Division for Medicinal Chemistry & Chemical Biology (DMCCB)

 Basel, Switzerland    November 16-18, 2023

Programme


08:00

Registration

09:00

Opening Ceremony

Dr Yves P. AUBERSON
NOVARTIS & EFMC, Basel, Switzerland
Prof. Maja KÖHN
UNIVERSITY OF FREIBURG, Freiburg, Germany
09:15

PL01 - Moving Undruggable Discoveries into the Drug Discovery Pipeline with Chemical Biology

Dr John TALLARICO
NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, Cambridge, United States

Session 1: Chemical Proteomics in Drug Discovery

Session Chair

Dr Sebastian ESSIG
BAYER AG, Wuppertal, Germany
10:00

KL01 - Chemoproteomics Approaches and their Contributions to Drug Discovery

Dr Marcus BANTSCHEFF
CELLZOME/GSK, Heidelberg, Germany
10:45

Coffee Break, Networking & Exhibition

11:15

IL01 - Towards Covalent Inhibitors Addressing Diverse Amino Acids

Dr Stephan HACKER
LEIDEN UNIVERSITY, Leiden, The Netherlands
11:40

IL02 - ABPP and its Impact on Drug Discovery - Successful Examples from the MAGL Program

Dr Uwe GRETHER
F. HOFFMANN-LA ROCHE, Basel, Switzerland
12:05

OC01 - Lessons for Covalent Drug Development from Deep Chemoproteomic Profiling of Approved Covalent Drugs

Dr Micah NIPHAKIS
LUNDBECK, San Diego, CA, United States
12:25

Lunch, Networking & Exhibition

12:30

Company Workshop by WuXi AppTec
Emerging Modalities in Drug Discovery

Dr Tao GUO
WUXI APPTEC, St Pauls, United States

Session 2: Computational Chemical Biology (LS-EuChemS Session)

Session Chair

Dr Sonsoles MARTIN-SANTAMARIA
CIB-CSIC, Madrid, Spain
13:55

KL02 - Unravelling the Molecular Mechanism of Pre-mRNA Splicing via All-atom Simulations

Prof. Alessandra MAGISTRATO
CNR-IOM, Trieste, Italy
14:40

IL03 - Challenges in Simulating Molecular Recognition Using Coarse-grain Models

Prof. Manuel MELO
UNIVERSITY NOVA DE LISBOA, Oeiras, Portugal
15:05

OC02 - Molecular Binding Studies in G Protein Coupled Receptors: Insights for Drug Discovery

Prof. Vittorio LIMONGELLI
UNIVERSITÀ DELLA SVIZZERA ITALIANA USI, Lugano, Switzerland
15:30

Coffee Break, Networking & Exhibition

Session 3: Chemically Induced Proximity

Session Chair

Prof. Gonçalo BERNARDES
UNIVERSITY OF CAMBRIDGE & IMM LISBOA, Cambridge, United Kingdom
16:00

OC03 - Molecular Glues for the 14-3-3 Interactome

Dr Richard DOVESTON
UNIVERSITY OF LEICESTER, Leicester, United Kingdom
16:20

IL04 - Tumor Targeting

Prof. Dario NERI
ETH ZÜRICH, Zürich, Switzerland
16:45

IL05 - Small Molecule Therapeutics Targeting Fibroblast Activation Protein in the Tumor Microenvironment

Dr Samuele CAZZAMALLI
PHILOCHEM AG, Otelfingen, Switzerland
17:10

KL03 - Chemogenetic and Optogenetic Technologies for Probing Molecular and Cellular Networks (Virtual Lecture)

Prof. Alice TING
STANFORD UNIVERSITY, Stanford, United States
17:55

Poster Session I (Odd), Networking & Exhibition

18:30

Welcome Reception & Poster Session I (Odd), Networking & Exhibition

19:30

End of the Day

Chair

Prof. Gianluca SBARDELLA
UNIVERSITY OF SALERNO, Fisciano, Italy
09:00

PL02 - Ribozymes Meet RNA Modifications


Prof. Claudia HÖBARTNER
UNIVERSITY OF WÜRZBURG, Würzburg, Germany

Session 4: Target Engagement and Mechanism of Action Determination

Session Chair

Dr Andrew ZHANG
ASTRAZENECA, Waltham, United States
09:45

KL04 - Mechanistic Insight in Drug Discovery: Past Tense of Future Direction? (Virtual Lecture)

Dr Rachel GRIMLEY
CANCER RESEARCH HORIZONS (CANCER RESEARCH UK), Cambridge, United Kingdom
10:30

Coffee Break, Networking & Exhibition

11:00

IL06 - Biophysical Proteomics

Dr Mikhail SAVITSKY
EUROPEAN MOLECULAR BIOLOGY LABORATORY, Heidelberg, Germany
11:25

IL07 - Proteomics Profiling of PROTACs and E3 Modulators to Identify Mechanistic Biomarkers and Substrates

Dr Meha SINGH
ASTRAZENECA, Waltham, United States
11:50

OC04 - Morphological Profiling of Small Molecules Using the Cell Painting Assay

Dr Slava ZIEGLER
MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY, Dortmund, Germany
12:10

Lunch, Networking & Exhibition

Session 5: Protein Conformations: Beyond the Ground State

Session Chair

Dr Wolfgang JAHNKE
NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, Basel, Switzerland
13:40

KL05 - Evolution of Energy Landscapes and its Exploitation for Drug and Enzyme Design

Prof. Dorothee KERN
BRANDEIS UNIVERSITY, Waltham, United States
14:25

IL08 - Low Molecular Weight Inhibitors of IL-1β: from a 19F NMR Fragment Hit to a Cellular Proof of Concept

Dr Anna VULPETTI
NOVARTIS, Basel, Switzerland
14:50

IL09 - NMR Provides Unique Insight into the Role of Disorder in Highly Dynamic Viral Replication Assemblies

Prof. Martin BLACKLEDGE
INSTITUT DE BIOLOGIE STRUCTURALE (IBS), Grenoble, France
15:15

OC05 - Spatiotemporally Controlled Generation of NTPs as A Versatile Tool for Single-Molecule Studies

Prof. Sebastian DEINDL
UPPSALA UNIVERSITY, Uppsala, Sweden
15:35

Coffee Break, Networking & Exhibition

Session 6: Targeting Metabolism (ICBS Session)

Session Chair

Prof. Zaneta NIKOLOVSKA-COLESKA
UNIVERSITY OF MICHIGAN, Ann Arbor, United States
16:05

KL06 - Understanding the Role of Metabolism in Cancer

Prof. Matthew G. VANDER HEIDEN
MIT, Cambridge, United States
16:50

IL10 - Chemical Biology of Sterol-mediated Processes

Dr Luca LARAIA
TECHNICAL UNIVERSITY OF DENMARK, Kgs. Lyngby, Denmark
17:15

OC06 - The Hidden Activator Within the Inhibitor: Regulated Tissue-Selective Inhibition and Activation of the Sugar Tolerance Transcription Factor ChREBP

Dr Maren HEIMHALT
LUDWIG MAXIMILIAN UNIVERSITÄT, Planegg-Martinsried, Germany
17:35

Poster Session II (Even), Networking & Exhibition

19:10

End of the Day

20:15

Symposium Banquet

Chair

Prof. Dennis GILLINGHAM
UNIVERSITY OF BASEL, Basel, Switzerland
09:00

PL03 - The Second Dimension of the Genetic Code

Prof. Thomas CARELL
LUDWIG-MAXIMILIANS-UNIVERSITY, München, Germany

Session 7: Chemical Immunology & Checkpoint Inhibitors

Session Chair

Prof. Nina HARTRAMPF
UNIVERSITY OF ZURICH, Zürich, Switzerland
09:45

KL07 - Fluorescent Amino Acids and Peptides for Translational Imaging of Infection and Inflammation in Humans

Prof. Marc VENDRELL
UNIVERSITY OF EDINBURGH, Edinburgh, United Kingdom
10:30

Coffee Break, Networking & Exhibition

11:00

IL11 - Chemoenzymatic and Metabolic Protein Labeling Strategies

Dr Kimberly BONGER
RADBOUD UNIVERSITY, Nijmegen, The Netherlands
11:25

IL12 - Chemical Immunology Tools for Synthetic Adjuvant and Vaccine Development

Dr Alberto FERNÁNDEZ-TEJADA
CIC BIOGUNE, Derio (Bizkaia), Spain
11:50

OC07 - Collectin-11 Antagonists in a Therapeutic Approach to Minimize Complement-Mediated Immune Injury

Dr Rachel HEVEY
UNIVERSITY OF BASEL, Basel, Switzerland
12:10

Lunch, Networking & Exhibition

Session 8: New Understandings of Post-translational Protein Modifications

Session Chair

Prof. Christian A. OLSEN
UNIVERSITY OF COPENHAGEN, Copenhagen, Denmark
13:40

KL08 - Chemical Approaches to Studying Chromatin

Prof. Tom MUIR
PRINCETON UNIVERSITY, Princeton, United States
14:25

IL13 - Beyond Phosphorylation – Protein Pyrophosphorylation by Inositol Pyrophosphate Messengers

Prof. Dorothea FIEDLER
LEIBNIZ-FORSCHUNGSINSTITUT FÜR MOLEKULARE PHARMAKOLOGIE (FMP), Berlin, Germany
14:50

IL14 - Decoding PTM Signaling from Chromatin to the Cytoskeleton

Prof. Beat FIERZ
ECOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE, Lausanne, Switzerland
15:15

OC08 - PhotoCrot: a Precise Photo-Chemical Approach to Selectively Identify Crotonylated Proteins

Dr Rita PETRACCA
UTRECHT UNIVERSITY, Utrecht, The Netherlands
15:35

Coffee Break, Networking & Exhibition

Session 9: EFMC-WuXi AppTec Award for Excellence in Chemical Biology

Session Chair

Prof. Rui MOREIRA
UNIVERSITY OF LISBON, Lisbon, Portugal
16:05

Award Ceremony

Prof. Rui MOREIRA
UNIVERSITY OF LISBON, Lisbon, Portugal
Dr Tao GUO
WUXI APPTEC, St Pauls, United States
16:20

PL04 - EFMC-WuXi AppTec Award for Excellence in Chemical Biology Lecture:
Translational Chemical Biology

Prof. Gonçalo BERNARDES
UNIVERSITY OF CAMBRIDGE & IMM LISBOA, Cambridge, United Kingdom
17:05

Poster Prizes Ceremony

Prof. Yimon AYE
ECOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE (EPFL), Lausanne, Switzerland
17:20

Closing Remarks

Dr Yves P. AUBERSON
NOVARTIS & EFMC, Basel, Switzerland
17:25

End of the Symposium